Diabetes Reasons

The reasons of diabetes depends on the type.

Type 1 diabetes is partly inherited and then triggered by certain infections, with some evidence pointing at Coxsackie B4 virus. There is a genetic element in individual susceptibility to some of these triggers which has been traced to particular HLA genotypes . However, even in those who have inherited the susceptibility, type 1 diabetes mellitus seems to require an environmental trigger.

Type 2 diabetes is due primarily to lifestyle factors and genetics.
There are many risk factors for type 2 diabetes, including:

* Age over 45 years
* A parent, brother, or sister with diabetes
* Gestational diabetes or delivering a baby weighing more than 9 pounds
* Heart disease
* High blood cholesterol level
* Obesity
* Not getting enough exercise
* Polycystic ovary disease (in women)
* Previous impaired glucose tolerance

Following is a comprehensive list of other causes of diabetes:

* Genetic defects of β-cell Function
o Maturity onset diabetes of the young (MODY)
o Mitochondrial DNA mutations
* Genetic defects in insulin processing or insulin action
o Defects in proinsulin conversion
o Insulin gene mutations
o Insulin receptor mutations
* Exocrine Pancreatic Defects
o Chronic pancreatitis
o Pancreatectomy
o Pancreatic neoplasia
o Cystic fibrosis
o Hemochromatosis
o Fibrocalculous pancreatopathy

* Endocrinopathies
o Growth hormone excess (acromegaly)
o Cushing syndrome
o Hyperthyroidism
o Pheochromocytoma
o Glucagonoma
* Infections
o Cytomegalovirus infection
o Coxsackievirus B
* Drugs
o Glucocorticoids
o Thyroid hormone
o β-adrenergic agonists